AlzeCure Pharma AB (publ) (FN STO: ALZCUR), a pharmaceutical company that develops a broad portfolio of small molecule drug candidates for diseases affecting the central nervous system, with projects in both Alzheimer’s disease and pain, today announced that the company’s presentation and poster regarding the research platform in neurology, Alzstatin, as presented at the 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022 in Uppsala, Sweden, are now available in its entirety on the company's website.
The poster, titled Development of novel gamma-secretase modulators for the treatment of Alzheimer’s disease, was presented by Dr. Maria Backlund and contains new preclinical data showing potent effects on amyloid production indicating that Alzstatin is a promising disease modifying and preventive therapy for the treatment of early Alzheimer’s disease.
The presentation included data on the effects of AC-0027875, a novel potent compound from the Alzstatin platform, on Aβ42 reduction in cells and animals.
AC-0027875 efficiently reduced Aβ42 production in cells and lowered Aβ42 in the brain in a time-dependent manner. The compound also displayed good pharmacokinetic properties and further studies with the compound is currently in progress.
“Aggregation of toxic amyloid beta, Aβ42, results in amyloid plaque formation – a process that plays a pivotal role in early Alzheimer’s disease pathogenesis. γ-Secretase modulators, so called GSMs, represent a promising class of Aβ42-lowering anti-amyloidogenic compounds that differentiates from antibody therapies and our compounds in Alzstatin are excellent examples of that,” said Martin Jönsson, CEO at AlzeCure Pharma.
The presentation, the poster and the abstract are available on AlzeCure’s website: (https://www.alzecurepharma.se/en/presentations-and-interviews/ ).
